DNA polymerases synthesize new DNA in which direction?

Study for the DNA Structure, Replication, Transcription and Translation Test with flashcards and multiple choice questions. Each question offers hints and explanations. Prepare thoroughly and excel in your exam!

Multiple Choice

DNA polymerases synthesize new DNA in which direction?

Explanation:
DNA polymerases can only add nucleotides to the 3' end of a growing DNA strand. Each incoming dNTP is joined to the 3'-OH of the previous nucleotide, forming a phosphodiester bond and releasing pyrophosphate. This requirement means the new strand is synthesized in the 5' to 3' direction, even though the template is read in the opposite 3' to 5' direction. This rule applies on both the leading and lagging strands, with the lagging strand made in short Okazaki fragments that are later joined.

DNA polymerases can only add nucleotides to the 3' end of a growing DNA strand. Each incoming dNTP is joined to the 3'-OH of the previous nucleotide, forming a phosphodiester bond and releasing pyrophosphate. This requirement means the new strand is synthesized in the 5' to 3' direction, even though the template is read in the opposite 3' to 5' direction. This rule applies on both the leading and lagging strands, with the lagging strand made in short Okazaki fragments that are later joined.

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